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pentobarbital will lower the extent or impact of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. steer clear of or Use Alternate Drug. Coadministration of abemaciclib with robust CYP3A4 inducers lowers plasma concentration of abemaciclib and its metabolites. pentobarbital will lower the level or result of mestranol by impacti